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Mister Dread was a member of the Men in Black and the leader of three designated to guard the vault.
Dread was part of a mission of the Alliance of Shades to stop humans realising the truth about the Grey aliens. He tracked down the Tenth Doctor, Cassie and Jimmy, but was damaged by Night Eagle. He managed to rebuild himself and retrieve the ionic fusion bar, bringing it back to Dreamland, where he was apparently destroyed by the sonic screwdriver.
In 1972 the Alliance of Shades was disbanded and the majority of his kind were decommissioned as a result. Despite this, the Alliance were unable to remove their hyperdimensional vault connected to St Jude's Hospital, where they stored their confiscated alien equipment. In light of this, Dread and two androids were re-assigned to guard the vault indefinitely. One of the activation disks for the vault was left in the care of Ocean Waters, while the other found its way off-planet.
In 2010, Dread and two other agents were located in St Jude's Hospital. When Androvax (in the body of a human teenage girl) entered the Hospital, Dread and the others were awoken by the perimeter alarms and chased him off. He and the other agents stopped Sarah Jane Smith after Androvax sent her and the others there to free his people. When he discovered that Sarah Jane had taken a clipping of Ocean Waters's abduction by aliens, he and the other agents attacked Ocean's house. Androvax managed to escape in Gita Chandra's body; Dread followed him, commandeering a van to the vault. He tried to use Gita and Rani Chandra as bait but was ambushed by Clyde and put back in his box, only to be activated soon after by Sarah Jane so he could use his power supply to transmat the Veil ship into space, saving Earth. Dread had used 450 years of power through that act, but since the vault had been sealed with Androvax's departure he had no further purpose and decided to deactivate himself. As suggested by Sarah Jane, he used some of his remaining power to wipe Gita's mind of her alien encounters before retiring.