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Susan was the granddaughter of the human scientist Dr. Who, who invented the time and space machine Tardis. She lived with him and her elder sister Barbara in a cottage in England.
Susan shared her grandfather's genius and passion for science, and this contributed to her being a highly precocious child.
She accompanied Dr. Who on his first trip to the planet Skaro in Tardis, as did Barbara and her boyfriend Ian Chesterton. During her travels, she met the Daleks.
Dr. Who, Susan, Louise and a police constable named Tom Campbell later travelled to London in 2150 and found that it had been devastated by a Dalek invasion years earlier. Once there, she assisted in freeing Earth from Dalek occupation.